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OCR: tion Cushing's syndrome is the clinical con propriate resulting from prolonged, excessive, in ulating exposure to free (non protein-bound) ci d clinically glucocorticoids. It was first fully describe lation of by Harvey Cushing in 1932 before the is , although either the adrenal or pituitary hormon labetes of many earlier cases, often referred to as bearded women', had been recognised. sults from Cushing's syndrome most commonly ticoids or the therapeutic use of synthetic glucoco adrenocorticotrophic hormone (ACTH)